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. 2023 Mar;75(2):263–308. doi: 10.1124/pharmrev.122.000654

Scheme 8.

Scheme 8

Synthesis of fluorescent MTs CLR16 and CLR18 by click chemistry starting from the new key intermediate monobutynyl MT. This protocol appears to be generally applicable to almost any given terminal azide and allows the introduction of one additional functional unit onto CLR01.