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. 2023 Mar;75(2):263–308. doi: 10.1124/pharmrev.122.000654

TABLE 1.

Dissociation constants for MTs with Lys- or Arg-containing amino acids and peptides determined by fluorometric titration experiments^a

Guest	K_d (µM)
	CLR01	CLR02	CLR04	CLR05
Ac-Lys-OMe	17^b 9^c	68^b	28^b 19^c	226^b 643^c
H-Lys-OH	21^b	874^b	227^c	1170^d
KAA	30^b	905^b	303^c	33333^d
KLVFF	20^b		38^c
KKLVFF	4^b	71^b
KKLVFFAK	7^b
KKKK	10^b
Ac-Arg-OMe	60^b 20^c		178^b 77^d	882^b 281^d
H-Arg-OH			699^b^,^c	609^d
H-Arg-OMe			160^c
RGD	86^b
cRGDfV	59^c
cGRGDfL	26^d
IAPP_1-7	9
IAPP_2-14	104
IAPP_2-7	No binding

^aDutt et al. (2013a) and Lopes et al. (2015).

^bPhosphate buffer 200 mM, pH=7.6.

^cPhosphate buffer 10 mM, pH=7.6.

^dPhosphate buffer 10 mM, pH=7.2.