TABLE 6.
CYP450 inhibition
| CYP450 Isoform | Standard IC50 (μM) | CLR01 IC50 (μM) |
|---|---|---|
| 1A2 | 0.51 (naphthoflavone) | >20 |
| 2D6 | 0.03 (quinidine) | 3.6 |
| 2C9 | 0.33 (sulphaphenazole) | 2.2 |
| 2C19 | 3.6 (troglitazone) | 1.5 |
| 3A4 | 0.03 (ketaconazole) | 1.7 |
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