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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Stat Med. 2021 Feb 2;40(7):1767–1789. doi: 10.1002/sim.8869

Figure 11.

Figure 11.

ESCC data (probe 209644). Top left: Egg shaped 95% confidence region for the sensitivity and specificity at the Youden-based estimated cutoffs. Top right: Underlying kernel densities of the healthy and the diseased. Middle: Surfaces of sensitivity and specificity along with the estimated Youden-based optimal pair of cutoffs. Bottom left: Contour plot of the surface of sensitivity for all possible cutoffs, along with the estimated Youden-based optimal pair of cutoffs (black dot). Bottom right: Contour plot of the surface of specificity for all possible cutoffs, along with the estimated Youden-based optimal pair of cutoffs (black dot).