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. 2023 Jan 30;51(4):1571–1582. doi: 10.1093/nar/gkad004

Figure 1.

Figure 1.

Dominant DNA conformations and conformational distributions of the telomeric repeat construct (Tel8). (A) Nucleotide sequence of Tel8 with positions of cyanine dyes (Cy3 and Cy5) and biotin (bio) labeling. L0–8 define the TTA linker position relative to the 5′ end of the DNA construct. (B) FRET histograms of single-molecule data from single-molecule analysis of Tel8 in the presence of 50 mM LiCl, KCl or NaCl. (C) CD spectra of unlabeled Tel8 in the presence of 50 mM LiCl, KCl or NaCl. (D) Schematic drawing of consecutive G-quadruplexes, either in a hybrid–hybrid conformation or in a basket–basket conformation (lower). Star and sphere indicate positions of Cy3 and Cy5 fluorophores, respectively.