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. 2023 Jan 30;51(4):1571–1582. doi: 10.1093/nar/gkad004

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Model for long telomeric repeat G-quadruplex formation. Kinetic folding: G-quadruplexes form randomly in long telomeric DNA leaving up to three unused repeats between units noted by black lines. Tight folding: DNA folding with consecutive G-quadruplexes results in thermodynamically favored states; G-quadruplexes can fold in different conformations. Equilibrium: Due to the many partly folded states compared to the tightly packed consecutive G-quadruplexes, spacing will be present at equilibrium.