Box 1. Future directions in suicide genetics.

• Within-person longitudinal studies of functional genomics

• Intergenerational studies

• Integration of genetic and psychosocial measures of risk

• Integration of multi-omics data (e.g., epigenomics, proteomics, metabolomics)

• Family studies, consanguineous families

• Polygenic risk score studies of mechanistic pathways to risk

• Larger and better-powered GWAS with ancestrally diverse populations

• GWAS of youth, specific self-injurious thoughts and behaviors, and other subgroups