TABLE 1.
THE ENDOMETRIAL DIFFERENTIALLY EXPRESSED GENES THAT MAY CONTRIBUTE TO THE ABNORMAL COLLECTIVE CELL MIGRATION IN WOMEN WITH ADENOMYOSIS
| Gene symbol | Log2FC | P-value | Biological processes |
|---|---|---|---|
| MYO3A | 2.13597894 | 0.025098694 | Cell–cell cohesion and coupling |
| GJB2 | 2.06355172 | 0.04771312 | Cell–cell cohesion and coupling (gap junction) |
| GJB3 | 2.824542409 | 0.004018079 | Cell–cell cohesion and coupling (gap junction) |
| GJB4 | 3.739644004 | 0.00401793 | Cell–cell cohesion and coupling (gap junction) |
| GJB5 | 6.246065184 | 0.002934825 | Cell–cell cohesion and coupling (gap junction) |
| ITGB6 | 2.663983313 | 0.002239706 | Cell–cell cohesion and coupling (integrin) |
| ICAM1 | 4.013325458 | 3.38E-07 | Cell–cell cohesion and coupling |
| ICAM4 | 2.487438086 | 0.017262748 | Cell–cell cohesion and coupling |
| CLDN14 | 3.483301242 | 0.00244102 | Cell–cell cohesion and coupling (tight junction) |
| CLDN6 | 3.037327159 | 0.010841124 | Cell–cell cohesion and coupling (tight junction) |
| CLDN8 | −2.527504706 | 0.037041349 | Cell–cell cohesion and coupling (tight junction) |
| MMP9 | 3.84882174 | 1.98E-06 | Forming a migration track, ECM remodelling |
| MMP1 | 8.041923495 | 1.07E-05 | Forming a migration track, ECM remodelling |
| MMP10 | 5.1870582 | 0.002465975 | Forming a migration track, ECM remodelling |
| MMP12 | 2.769143318 | 0.001400788 | Forming a migration track, ECM remodelling |
| MMP13 | 4.002987481 | 0.00255607 | Forming a migration track, ECM remodelling |
| MMP27 | 4.156066119 | 0.002233888 | Forming a migration track, ECM remodelling |
| MMP3 | 6.455516004 | 0.000462347 | Forming a migration track, ECM remodelling |
| MMP7 | 2.279017256 | 0.019064915 | Forming a migration track, ECM remodelling |
| MMP8 | 10.39749709 | 0.000220408 | Forming a migration track, ECM remodelling |
| HAS1 | 2.77613436 | 0.02534036 | Forming a migration track, ECM remodelling |
| HAS2 | 2.85980488 | 0.00077117 | Forming a migration track, ECM remodelling |
| HAS3 | 2.73840812 | 1.92E-05 | Forming a migration track, ECM remodelling |
| LAMB3 | 2.899319784 | 0.008113949 | Forming a migration track, ECM remodelling |
| COL28A1 | −2.049272211 | 0.002893567 | Forming a migration track, ECM remodelling |
| CXCL1 | 3.437751705 | 0.001022512 | Driving force of guided cell migration |
| CXCL10 | 2.466611485 | 0.00463707 | Driving force of guided cell migration |
| CXCL13 | −5.778651129 | 2.00E-05 | Driving force of guided cell migration |
| CXCL14 | −3.86665238 | 0.000483943 | Driving force of guided cell migration |
| CXCL2 | 3.427204022 | 0.00020155 | Driving force of guided cell migration |
| CXCL3 | 3.714065968 | 6.73E-06 | Driving force of guided cell migration |
| CXCL5 | 5.128974018 | 3.87E-06 | Driving force of guided cell migration |
| CXCL6 | 3.676691233 | 0.001805715 | Driving force of guided cell migration |
| CXCL8 | 4.550862093 | 8.02E-06 | Driving force of guided cell migration |
ECM, extracellular matrix.