Table 2A.
Patient and Treatment Characteristics
| No. of Patients (%) | |||
|---|---|---|---|
|
| |||
| Characteristic | Radiation Resistance WT or VUS (n = 73) | Radiation Resistance mt (n = 16) | p – value |
|
| |||
| Age | 0.006 | ||
| Median, Range (years) | 68 (52 – 83) | 64 (46 – 79) | |
|
| |||
| Ever Smoker | 0.104 | ||
| Yes | 55 (75) | 15 (94) | |
|
| |||
| Sex | 0.665 | ||
| Female | 46 (63) | 11 (69) | |
| Male | 27 (37) | 5 (31) | |
|
| |||
| Performance Status | 0.689 | ||
| ECOG 0 | 45 (62) | 9 (56) | |
| ECOG 1 | 28 (38) | 7 (44) | |
|
| |||
| Histology | 0.391 | ||
| Adenocarcinoma | 65 (89) | 13 (81) | |
| Other | 8 (11) | 3 (19) | |
|
| |||
| Tumor Mutational Burden | 0.163 | ||
| Median, IQR (mt/Mb) | 6.1 (2.6–10.5) | 10.5 (6.1–15.8) | |
|
| |||
| AJCC 8th Overall Stage | 0.672 | ||
| < III | 7 (10) | 1 (6) | |
| IIIA or IIIB | 66 (90) | 15 (94) | |
|
| |||
| Margin Status | 0.985 | ||
| Negative | 64 (88) | 14 (88) | |
| Positive | 9 (12) | 2 (12) | |
|
| |||
| Involved Mediastinal Nodal Stations | 0.158 | ||
| <2 | 54 (74) | 9 (56) | |
| ≥2 | 19 (26) | 7 (44) | |
|
| |||
| Received Chemotherapy | 0.116 | ||
| Yes | 63 (86) | 16 (100) | |
|
| |||
| Received ICI | 0.350 | ||
| Yes | 11 (15) | 1 (6) | |
|
| |||
| Received TKI | 0.113 | ||
| Yes | 10 (14) | 0 | |
|
| |||
| Radiation Dose | 0.616 | ||
| Median, range (Gy) | 54 (50 – 60) | 54 (50.4 – 60) | |
|
| |||
| Radiation Technique | |||
| 3D-CRT | 15 (20) | 3 (19) | 0.871 |
| IMRT | 58 (80) | 13 (81) | |