Table 2B.
Patient and Treatment Characteristics
| No. of Patients (%) | |||
|---|---|---|---|
|
| |||
| Characteristic | DDR WT or VUS (n = 74) | DDR mt (n = 15) | p – value |
|
| |||
| Age | 0.951 | ||
| Median, Range (years) | 68 (46 – 83) | 69 (52 – 80) | |
|
| |||
| Ever Smoker | 0.406 | ||
| Yes | 57 (77) | 13 (87) | |
|
| |||
| Sex | 0.720 | ||
| Female | 48 (65) | 9 (60) | |
| Male | 26 (35) | 6 (40) | |
|
| |||
| Performance Status | 0.523 | ||
| ECOG 0 | 46 (62) | 8 (53) | |
| ECOG 1 | 28 (38) | 7 (46) | |
|
| |||
| Histology | 0.9 | ||
| Adenocarcinoma | 65 (88) | 13 (87) | |
| Other | 9 (12) | 2 (13) | |
|
| |||
| Tumor Mutational Burden | 0.003 | ||
| Median, IQR (mt/Mb) | 6.1 (3–10.5) | 14 (7.9–19.4) | |
|
| |||
| AJCC 8th Overall Stage | 0.182 | ||
| < III | 8 (11) | 0 | |
| IIIA or IIIB | 66 (89) | 15 (100) | |
|
| |||
| Margin Status | 0.9 | ||
| Negative | 65 (88) | 13 (87) | |
| Positive | 9 (12) | 2 (13) | |
|
| |||
| Involved Mediastinal Nodal Stations | 0.314 | ||
| <2 | 54 (73) | 9 (60) | |
| ≥2 | 20 (27) | 6 (40) | |
|
| |||
| Received Chemotherapy | 0.778 | ||
| Yes | 66 (89) | 13 (87) | |
|
| |||
| Received ICI | 0.397 | ||
| Yes | 11 (15) | 1 (7) | |
|
| |||
| Received TKI | 0.587 | ||
| Yes | 9 (12) | 1 (7) | |
|
| |||
| Radiation Dose | 0.616 | ||
| Median, range (Gy) | 54 (50 – 60) | 54 (50 – 60) | |
|
| |||
| Radiation Technique | |||
| 3D-CRT | 16 (22) | 2 (13) | 0.862 |
| IMRT | 58 (78) | 13 (87) | |