Table 3:

Predictors for Local-Regional Failure After PORT

	Univariate		Multivariate
	HR (95% CI)	p - value	HR (95% CI)	p - value
Age	1.01 (0.95 – 1.06)	0.84
Sex	1.67 (0.7 – 3.96)	0.25
ECOG 0	1.47 (0.62 – 3.46)	0.38
Margin Status	1.27 (0.37 – 4.29)	0.71
Involved N2 Stations	2.05 (0.84 – 4.97)	0.11
Receipt of ICI	0.53 (0.12 – 2.29)	0.39
Receipt of TKI	0.32 (0.04 – 2.39)	0.27
TMB	0.91 (0.83–0.99)	0.04	0.86 (0.77 – 0.97)	0.01
Radiation Resistance mut	5.41 (2.26–12.94)	<0.001	7.42 (2.83 – 19.44)	<0.001

Age assessed as continuous variable. Sex (male vs female [ref]); ECOG 0 [ref] vs ECOG 1. Margin status (positive vs negative [ref]). Involved N2 stations (2 stations [ref] vs ≥2 stations). Receipt of ICI (yes [ref] vs no). Receipt of TKI (yes [ref] vs no). TMB assessed as continuous variable. Radiation Resistance mut (yes vs no [ref]).