Table 3.
Spearman correlation of plasma BD-tau versus NfL with regional plaque and tangle pathologies biomarkers in the Neuropathology cohort
| Plasma BD-tau | Plasma NfL | |
|---|---|---|
| Global measures | ||
| Neuritic plaques | rho = 0.58 (P < 0.0001) | rho = −0.06 (P = 0.6708) |
| Diffuse plaques | rho = 0.56 (P < 0.0001) | rho = −0.06 (P = 0.6686) |
| Regional measures | ||
| Neuritic plaques | ||
| ȃHippocampal | rho = 0.53 (P = 0.0066) | rho = −0.14 (P = 0.5009) |
| ȃSuperior temporal | rho = 0.52 (P = 0.0079) | rho = −0.13 (P = 0.5312) |
| ȃInferior parietal | rho = 0.68 (P = 0.0002) | rho = 0.17 (P = 0.4262) |
| Diffuse plaques | ||
| ȃHippocampal | rho = 0.55 (P = 0.0066) | rho = −0.13 (P = 0.5251) |
| ȃSuperior temporal | rho = 0.65 (P = 0.0004) | rho = 0.02 (P = 0.9382) |
| ȃInferior parietal | rho = 0.64 (P = 0.0005) | rho = 0.02 (P = 0.8994) |
| NFTs | ||
| ȃHippocampal | rho = 0.56 (P = 0.0033) | rho = 0.09 (P = 0.6848) |
| ȃSuperior temporal | rho = 0.55 (P = 0.0048) | rho = −0.05 (P = 0.8090) |
| ȃInferior parietal | rho = 0.55 (P = 0.0042) | rho = 0.01 (P = 0.9710) |
| ȃMiddle frontal | rho = 0.67 (P = 0.0003) | rho = 0.03 (P = 0.8720) |