Table 1.
Cohort demographics
| Total | ADC | DEM | ADNI | ||||||
|---|---|---|---|---|---|---|---|---|---|
| ADC | DEM | ADNI | No AD | AD | No AD | AD | No AD | AD | |
| n | 80 | 92 | 43 | 43 | 37 | 8 | 84 | 12 | 31 |
| Demographics | |||||||||
| Sex (female) | 29 (36%) | 45 (49%) | 9 (21%) | 17 (40%) | 12 (32%) | 6 (75%) | 39 (46.4%) | 2 (16.7%) | 7 (23%) |
| Age at baseline, years | 62 (58–66) | 76 (71–84) | 78 (73–83) | 61 (56–65) | 63 (59–68) | 81 (77–83) | 76 (71–84) | 80 (76–83) | 77 (73–83) |
| Age at death, years | 67 (64–70) | 78 (73–86) | 83 (78–86) | 65 (61–69) | 69 (66–74)** | 83 (78–85) | 77 (72–86) | 84 (81–86) | 81 (77–86) |
| Time between CSF collection and death, years | 4 (2–6.1) | 0.5 (0.1–2.8) | 4.9 (3.1–7.1) | 3 (1.8–5.6) | 5.2 (3.1–7.4)** | 0.1 (0.1–1.6) | 0.6 (0.1–2.8) | 4.5 (3.5–6.7) | 5 (2.7–7.1) |
| APOE ε4 carrier | 36 (51%) | 35/64 (55%) | 21 (49%) | 16 (43%) | 20 (61%) | 1/4 (25%) | 34/60 (56.7%) | 0 (0%) | 21 (68%)*** |
| Clinical diagnosis | n = 7 | n = 74 | |||||||
| Cognitively normal | 3 (4%) | 0 | 7 (16%) | 1 (2%) | 2 (5%) | 0 | 0 | 4 (33.3%) | 3 (10%) |
| Mild cognitive impairment | 3 (4%) | 2 (2.5%) | 21 (49%) | 1 (2%) | 2 (5%) | 0 (0%) | 2 (2.7%) | 8 (66.7%) | 13 (42%) |
| AD dementia | 28 (35%) | 53 (65.4%) | 15 (35%) | 3 (7%) | 25 (68%)*** | 2 (28.6%) | 51 (68.9%) | 0 (0%) | 15 (48%)* |
| Non-AD dementia | 35 (44%)a | 14 (17.3%)b | — | 30 (70%) | 5 (14%)*** | 5 (71.4%) | 9 (12.2%)** | — | — |
| Other | 11 (14%)c | 12 (14.8%)d | — | 8 (19%) | 3 (8%) | 0 (0%) | 12 (16.2%) | — | — |
Cohort demographics of the ADC, DEM and ADNI cohort with comparisons made between the three cohorts and stratified for presence of pathological AD at autopsy. Results presented in n (%) or median (IQR).
Including dementia with Lewy bodies (no AD n = 1; AD n = 2), frontotemporal lobar degeneration (no AD n = 19; AD n = 2), primary progressive aphasia (no AD n = 2), vascular dementia (no AD n = 1) and other dementias (no AD n = 7; AD n = 1).
Including dementia with Lewy bodies (AD n = 1), frontotemporal lobar degeneration spectrum (no AD n = 1, AD n = 6), vascular dementia (no AD n = 1), Creutzfeldt-Jakob disease (no AD n = 2, AD n = 1), Parkinson's disease (no AD n = 1) and Charles Bonnet syndrome (AD n = 1).
Diagnosis either psychiatric disorder, neurologic non-neurodegenerative disorder or postponed diagnosis due to clinical uncertainty.
Diagnosis either mixed dementia (n = 3), unspecified dementia (n = 2) or clinical doubt between AD dementia and non-AD dementia (n = 7).
*** P < 0.001, ** P < 0.01, * P < 0.05 for AD versus no AD within cohort.