Table 1.
Demographic and clinical information of the cSLE cohort
| Variable | Category | Healthy controls (n = 20) | Inactive SLE (n = 28) | Active nonrenal (n = 17) | Active renala (n = 15) |
|---|---|---|---|---|---|
| Age, years, mean (s.d.) | 15.4 (0.86) | 16.1 (1.02) | 14.7 (1.16) | 14.5 (1.44) | |
| Gender, n (%) | Female | 20 (100) | 23 (82) | 15 (88) | 13 (87) |
| Male | N/A | 5 (18) | 2 (12) | 2 (13) | |
| Ethnicity, n (%) | Asian | N/A | 2 (7) | 1 (6) | 1 (7) |
| Black | 3 (15) | 5 (18) | 7 (41) | 6 (40) | |
| Caucasian | 9 (45) | 4 (14) | N/A | N/A | |
| Hispanic | 8 (40) | 17 (60) | 9 (53) | 7 (47) | |
| Other | N/A | N/A | N/A | 1 (7) | |
| Clinical assessment, mean (95% CI) | SLEDAI | 0 | 2.61 (1.07) | 5.53 (1.60) | 18.1 (4.07) |
| rSLEDAI | 0 | 1.00 (0.87) | 0 | 9.33 (1.98) | |
| Laboratory measurement | uPCR (mg/mg), mean (95% CI) | N/A | 0.13 (0.05) | 0.10 (0.03) | 4.54 (3.26) |
| Pyuria (0, 1), % | N/A | 14% | 0% | 40% | |
| Hematuria (0, 1), % | N/A | 4.0% | 0% | 73% | |
| Casts (0, 1), % | N/A | 0% | 0% | 33% | |
| Serum creatinine, mean (95% CI) | N/A | 0.62 (0.05) | 0.54 (0.10) | 0.68 (0.10) | |
| Glomerular filtration rate, mean (95% CI) | N/A | 108 (8.44) | 114 (11.0) | 134 (64.7) | |
| dsDNA antibodies (titer), % positive (mean [95% CI]) | N/A | 39% (560 [488]) | 65% (612 [378]) | 67% (1304 [505]) | |
| C3, mean (95% CI) | N/A | 115 (8.52) | 83.0 (16.2) | 49.4 (19.2) |
a
As ascertained by a renal biopsy, the active LN patients had a mean activity score of 3.36 (s.d. 4.34) and a mean CI score of 0.91 (s.d. 1.38), with the following GN class distribution: class 1 (n = 1), class 2 (n = 1), class 3 (n = 3), class 4 (n = 2), class 5 (n = 3), mixed (n = 4).