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. 2023 Jan;33(1):141–153. doi: 10.1101/gr.277301.122

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© 2023 Teefy et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see https://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — Differential gene expression analysis and GO biological process functional enrichment analysis with ovarian aging. (A) Scheme used for differential gene expression (DGE) analysis. DGE performed with DESeq2 likelihood ratio testing (LRT) revealed four groups of differentially expressed genes corresponding to expression down at middle-age (a), up at middle-age (b), down with age (c), and up with age (d). (B) Heatmaps of gene expression for genes significantly regulated with age in aging killifish ovaries by DESeq2 LRT (FDR < 10⁻⁶). (C) Functional enrichment analysis for each gene cluster in B, showing the top 10 significant GO “biological process” terms (FDR < 5%) (for complete list, see Supplemental Table S3A). The most significant term down-regulated in middle-aged ovaries is “piRNA metabolic process” (bolded). (FDR) False-discovery rate, (enrichment) fold enrichment over background.