Table 2.

Late-life Sleep Medication Use and Incident Dementia: ARIC Study (N = 4 197)^*

	Matched Nonusers (n = 2 798)	Sleep Medication Users (n = 1 399)
Incident dementia, n	367	265
Cumulative incidence	13.1%	18.9%
Incidence rate, per 100 person-years	2.11	3.17
Model†	Hazard ratio (95% confidence intervals)
Model 1	(reference)	1.53 (1.31, 1.79)
Model 2	(reference)	1.59 (1.36, 1.86)
Model 3	(reference)	1.50 (1.27, 1.76)
Model 4	(reference)	1.48 (1.26, 1.74)

Note: Bold text represents statistically significant results. ARIC = Atherosclerosis Risk in Communities; BMI = body mass index; CHD = coronary heart disease.

*Matched sample 2:1.

^†Model adjustments―Model 1: crude unadjusted; Model 2: adjusted for age, sex, race-center, education, and APOE ε4; Model 3: Model 2 + adjustment for smoking status, alcohol consumption, depressive symptoms, and BMI; Model 4: Model 3 + adjustment for systolic blood pressure, antihypertensive medications, prevalent diabetes, and prevalent CHD.