Figure 1.

Contributions of brain pathologies to grip strength and gait function decline. Model-derived trajectories of grip strength (A) and gait function (B) decline in an average 90-y-old women with 16 y of education and with increasing burden of brain pathologies. Neurodegenerative pathologies (tau tangles, nigral neuronal loss, and TDP-43 proteinopathy) were associated with a faster grip strength decline. By contrast, both neurodegenerative (tau tangles and nigral neuronal loss) and cerebrovascular disease (macroinfarcts and cerebral atherosclerosis) pathologies were associated with a faster gait function decline.