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. 2023 Jan 24;8(2):e163789. doi: 10.1172/jci.insight.163789

Figure 5. Vitamin D reduces inflammation, despite an exaggerated response to NM exposure.

Figure 5

(A) Venn diagram of the number of NM injury DEPs that are upregulated 72hrs P-I in Mild VitD(–) (n = 7) and VitD(+) (n = 5) relative to baseline (n = 24). Data are shown as mean ± SEM of NPX values for labeled groups. (B) Venn diagram shows the number of NM injury DEPs that are upregulated 72hrs P-I in Severe VitD(–) (n = 5) and VitD(+) (n = 7) relative to baseline. Data are shown as mean ± SEM of NPX values for labeled groups. (C) Venn diagram shows the number of NM injury DEPs that are upregulated 6wks P-I in Mild VitD(–) (n = 4) and VitD(+) (n = 7) relative to baseline. Data are shown as mean ± SEM of NPX values for labeled groups. (D) Venn diagram shows the number of NM injury DEPs that are upregulated 6wks P-I in Severe VitD(–) (n = 7) and VitD(+) (n = 5) relative to baseline. Data are shown as mean ± SEM of NPX values for labeled groups. (E) Dot plots of mean CBC levels; data are shown as mean ± SEM, with error bars at baseline and 24-hours P-I in Mild VitD(–) (n = 7), Mild VitD(+) (n = 5), Severe VitD(–) (n = 5), and Severe VitD(+) (n = 7). Two-way ANOVA followed by Tukey’s multiple-comparison test were used to determine statistical significance. *P < 0.05. (F) Dot plots over time of vitamin D metabolites 25(OH)2D3 and 1,25(OH)2D3. Two-way ANOVA followed by Tukey’s multiple-comparison test were used to determine statistical significance. *Padj < 0.05, **Padj < 0.01. (A–D) Significance was determined by linear mixed-effects modeling followed by Benjamini-Hochberg correction for multiple comparisons; *Padj < 0.05, **Padj < 0.01, ***Padj < 0.001, ****Padj < 0.0001.