Table 1.

Gene pathway analysis for IP and CP layer 3 PNs in DLPFC.

Pathway	Genes in pathway	DEGs (%) in pathway	q-Value	DEGs with higher expression in CP PNs	Genesa
Synaptogenesis Signaling Pathway	199	34 (17.1%)	2.3E−07	24	CACNA2D1, CAMK2D, CAMK2G, CDH10, CPLX1, CPLX2, CREB1, CTNNB1, DAB1, EFNB3, EPHA4, GRIA2, GRIA4, GRIN2A, GRM5, LIMK1, MAP1B, MRAS, NAPA, NECTIN3, NLGN1, NRXN1, NTRK2, PIK3R1, PRKACB, PRKAR1A, SNAP25, STX1B, SYN2, SYT12, SYT13, SYT16, SYT2, TIAM1
Calcium Signaling	100	20 (20%)	7.8E−06	16	AKAP5, ASPH, ATP2B4, CACNA2D1, CACNA2D2, CAMK2D, CAMK2G, CREB1, GRIA2, GRIA4, GRIN2A, HDAC9, MEF2A, MEF2C, MYH14, PNCK, PRKACB, PRKAR1A, RYR3, SLC8A1
Axonal Guidance Signaling	253	32 (12.6%)	0.001	24	ADAM23, ADAMTS1, ADAMTS15, ADAMTS4, ADAMTS8, BMP2, EFNB3, EPHA4, FZD3, GNB4, GNG4, HHIP, LIMK1, LRRC4C, MRAS, NTNG1, NTRK2, NTRK3, PAK5, PIK3R1, PLCL2, PLXNB2, PLXNC1, PRKACB, PRKAR1A, PRKD1, SEMA3C, SEMA3E, SEMA6D, SEMA7A, UNC5D, WNT7B
Neuropathic Pain Signaling in Dorsal Horn Neurons	69	14 (20.3%)	0.001	12	CAMK2D, CAMK2G, CREB1, ELK1, GRIA2, GRIA4, GRIN2A, GRM5, NTRK2, PIK3R1, PLCL2, PRKACB, PRKAR1A, PRKD1
Cardiac beta-adrenergic Signaling	80	14 (17.5%)	0.02	12	AKAP11, AKAP12, AKAP5, GNB4, GNG4, MPPED2, MRAS, PDE4B, PKIB, PKIG, PPP1CB, PRKACB, PRKAR1A, SLC8A1
Protein Kinase A Signaling	210	26 (12.4%)	0.03	23	AKAP11, AKAP12, AKAP5, CAMK2D, CAMK2G, CREB1, CTNNB1, DUSP6, ELK1, GNB4, GNG4, MPPED2, PDE4B, PLCL2, PPP1CB, PRKACB, PRKAR1A, PRKD1, PTPRA, PTPRF, PTPRG, PTPRR, PTPRT, RYR3, TCF4, YWHAZ

^aGenes in black are enriched in CP neurons and those in gray are enriched in IP neurons.