Table 4.

Pathway analysis for genes differentiating DLPFC and PPC layer 3 PNs.

Pathway	Genes in pathway	DEGs (%) in pathway	q-Value	DEGs with higher expression in DLPFC	Genesa
Synaptogenesis Signaling Pathway	199	55 (27.6%)	2.9E−05	36	ADCY2, ARHGEF7, BAD, CACNA2D1, CAMK2D, CAMK2G, CDH10, CDH11, CDH9, CNTNAP2, CPLX1, CPLX2, EFNB3, EPHA3, EPHA5, EPHA6, EPHB3, GRIA1, GRIA2, GRIA4, GRIN2B, GRM2, GRM5, GRM8, ITPR1, LIMK1, LRRTM2, MAP1B, MRAS, NAP1L1, NECTIN1, NECTIN3, NRXN3, PIK3CG, PIK3R3, PRKACB, PRKCD, RAP1B, RAP2B, RASD1, RASGRP1, RASGRP2, SNCG, STX1B, STXBP5, SYN3, SYNGAP1, SYT16, SYT17, SYT2, SYT9, THBS3, TIAM1, VAMP3, VLDLR
Glutamate Receptor Signaling	40	16 (40%)	0.013	13	GLUL, GNG7, GRIA1, GRIA2, GRIA4, GRID1, GRID2, GRIK2, GRIK4, GRIK5, GRIN2B, GRM2, GRM5, GRM8, HOMER1, SLC17A6

^aGenes in black are enriched in DLPFC layer 3 PNs and those in gray are enriched in PPC layer 3 PNs.