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. 2023 Mar 1;13(10):6909–6918. doi: 10.1039/d3ra00292f

Hydration of diverse nitriles catalysed by Ag-OMS-2a.

Entry Substrate Product Temp. (°C) Time (h) Isolated yield (%)
1 graphic file with name d3ra00292f-u1.jpg graphic file with name d3ra00292f-u2.jpg 80 4 93
2 graphic file with name d3ra00292f-u3.jpg graphic file with name d3ra00292f-u4.jpg 80 4 95
3 graphic file with name d3ra00292f-u5.jpg graphic file with name d3ra00292f-u6.jpg 80 4 91
4 graphic file with name d3ra00292f-u7.jpg graphic file with name d3ra00292f-u8.jpg 80 4 89
5 graphic file with name d3ra00292f-u9.jpg graphic file with name d3ra00292f-u10.jpg 80 4 92
6 graphic file with name d3ra00292f-u11.jpg graphic file with name d3ra00292f-u12.jpg 80 4 97
7 graphic file with name d3ra00292f-u13.jpg graphic file with name d3ra00292f-u14.jpg 80 4 96
8 graphic file with name d3ra00292f-u15.jpg graphic file with name d3ra00292f-u16.jpg 80 4 88
9 graphic file with name d3ra00292f-u17.jpg graphic file with name d3ra00292f-u18.jpg 80 4 90
10 CH3CN graphic file with name d3ra00292f-u19.jpg 100 9 70
11 graphic file with name d3ra00292f-u20.jpg graphic file with name d3ra00292f-u21.jpg 100 9 73
12 graphic file with name d3ra00292f-u22.jpg graphic file with name d3ra00292f-u23.jpg 80 4 95
13 graphic file with name d3ra00292f-u24.jpg graphic file with name d3ra00292f-u25.jpg 80 4 92
a

Reaction conditions: nitrile (1.0 mmol), Ag-OMS-2 (30 mg), H2O (4 mL), 80 °C. The products were isolated by either recrystallization or column chromatography, and confirmed by 1H NMR.