Hydration of diverse nitriles catalysed by Ag-OMS-2a.
| Entry | Substrate | Product | Temp. (°C) | Time (h) | Isolated yield (%) |
|---|---|---|---|---|---|
| 1 |
|
|
80 | 4 | 93 |
| 2 |
|
|
80 | 4 | 95 |
| 3 |
|
|
80 | 4 | 91 |
| 4 |
|
|
80 | 4 | 89 |
| 5 |
|
|
80 | 4 | 92 |
| 6 |
|
|
80 | 4 | 97 |
| 7 |
|
|
80 | 4 | 96 |
| 8 |
|
|
80 | 4 | 88 |
| 9 |
|
|
80 | 4 | 90 |
| 10 | CH3CN |
|
100 | 9 | 70 |
| 11 |
|
|
100 | 9 | 73 |
| 12 |
|
|
80 | 4 | 95 |
| 13 |
|
|
80 | 4 | 92 |
Reaction conditions: nitrile (1.0 mmol), Ag-OMS-2 (30 mg), H2O (4 mL), 80 °C. The products were isolated by either recrystallization or column chromatography, and confirmed by 1H NMR.