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. 2023 Feb 8;8(3):e163150. doi: 10.1172/jci.insight.163150

Figure 2. IgG anti-cytokine autoantibodies in serum from patients with ARDS or patients acutely infected with influenza virus.

Figure 2

Tukey box plots comparing MFI data for 8 cytokines in patients with influenza (n = 25) and patients with ARDS (n = 17), both collected prior to the COVID-19 pandemic; patients with ARDS who were COVID-19– (n = 19); and HC (n = 11). One COVID-19 PCR-negative patient from the Marburg cohort had high levels of antibodies targeting SARS-CoV-2 proteins from our viral array and was excluded from this figure and other analyses (Supplemental Figure 6). The middle line represents the median, while the lower and upper hinges correspond to the first and third quartiles. The upper whisker extends from the hinge to 1.5 times the IQR above the 75th percentile MFI value, and the lower whisker extends from the hinge to 1.5 times the IQR below the 25th percentile MFI value. Black arrows indicate a serum sample with receptor-blocking activity (see Figure 4). Individual MFI values 1.5 times the IQR above the 75th percentile or 1.5 times the IQR below the 25th percentile are displayed as dots. MFI is shown on the y axis, which is hatched to reflect outlier samples with very high MFI. Cohorts are shown on the x axis.