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. 2023 Feb 8;8(3):e163150. doi: 10.1172/jci.insight.163150

Figure 3. Newly detectable autoantibodies in acutely infected patients with influenza.

Figure 3

(A) Longitudinal measurements of specific ACA over time in acutely infected patients (n = 40). Serum was collected at 3 time points for 18 influenza individuals, at 2 time points for 13 influenza individuals, and at only the first time point for 9 individuals. The first time point (T1) is from the day that the patient was admitted to the hospital and diagnosed with influenza. T2 and T3 refer to approximately 1 week and 1 month, respectively, following hospital admission. Black arrows indicate a serum sample with receptor blocking activity (see Figure 4). (B) Newly detectable IgG autoantibodies recognize CTD autoantigens. Line plots display MFI levels of antibodies targeting traditional autoantigens that are inducible (SRP54 in individual AA19; TPO in individual AA23), fluctuate (TPO in individual AA13), or do not change significantly over time (most individuals with TPO autoantibodies, and 2 individuals with anti–PDC-E2).