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. 2023 Feb 8;8(3):e163762. doi: 10.1172/jci.insight.163762

Figure 1. α-SMA+ fibrotic fibroblasts express antiapoptotic BCL-2 family members in IPF and silicosis.

Figure 1

Immunofluorescence imaging of lungs from healthy donors, IPF, and silicosis for anti–α-SMA (red), DAPI (blue), and antiapoptotic BCL-2 family members (green): (A) BCL-2, (B) BCL-XL, (C) BCL-W, (D) MCL-1. (E–H) Semiquantitative scoring of colocalization of antiapoptotic BCL-2 family members in α-SMA+ cells: 0 (0%), 1 (1%–33%), 2 (34%–66%), 3 (67%–100%). n = 4–8 individuals per group. Ten images per slide were scored. Graphed as scatterplot with bar, mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, Brown-Forsythe and Welch’s ANOVA with Dunnett’s correction for multiple comparisons. Total magnification with objective 200×.