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. 2023 Feb 8;8(3):e163762. doi: 10.1172/jci.insight.163762

Figure 4. Ex vivo fibrotic fibroblasts are more primed than those from naive mice.

Figure 4

(A) Schematics demonstrating BCL-2 family member interactions controlling the intrinsic pathway of apoptosis. (A) Apoptosis through activator binding of pore formers and (B) primed phenotype (C) binding of sensitizers or BH3 mimetics displacing activators to drive apoptosis. (D) Schematic demonstrating the steps of BH3 profiling. (E) Representative flow cytometry plots of BH3 profiling and cytochrome c signal loss. BH3 profiling with (F) BIM (100 μM) and (G) BMF (100 μM). n = 5–8 mice per group. Graphed as scatterplot with bar, mean ± SEM. *P < 0.05, ***P < 0.001, 2-tailed t test with Welch’s correction.