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. 2023 Feb 8;8(3):e163762. doi: 10.1172/jci.insight.163762

Figure 6. ABT-263 reverses fibrosis during therapeutic intervention in persistent, progressive fibrosis.

Figure 6

(A) Hydroxyproline content of lungs, (B) semiquantitative histology scoring, and (C) representative trichrome images after vehicle or ABT-263 treatment. (D) Nonaerated lung volume as measured by micro-CT, with representative (E) axial images (red arrows indicate disease) and (F) 3D reconstructions (nonaerated lung in blue, aerated lung in gray). n = 3–9 mice per group. Graphed as scatterplot with bar, mean ± SEM, or time-course line graph with mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, 2-tailed t test with Welch’s correction. Total original magnification 2× (upper panels) and 20× (lower panels).