Figure 2. Strain-specific histological changes in the kidney upon folic acid injury.

Histology slides were scored by pathologist in a double-blind manner. (A) Representative images of severity grade 1–4 kidney tubule dilation, tubule degeneration, interstitial inflammation, and fibrosis. Strains and time points are indicated on the left, and severity grades are indicated on the right. (B) Heatmap of the severity grades of kidney histology in each strain and time point. Statistical significance is shown representing Wilcoxon test comparison between FA and control, using FDR-corrected P values (***P < 0.001, **P < 0.01,*P < 0.05).