TABLE 5.
BK virus-related events
| Subject | Management | Max | Max (Log10) | Biopsy |
|---|---|---|---|---|
| Q1M | ||||
| 010 | Biopsy for elevated SCr demonstrated severe BVN. Spaced bela to q6, stopped MMF, but remained log10 of 6 Transitioned to tacrolimus-based therapy |
5e6 | 6.7 | Y |
| 051 | Improved with reduced dose MMF | 2e5 | 5.3 | N |
| 090 | Improved with holding MMF | 1e4 | 4.0 | N |
| 160 | Improved with reduced dose MMF | 1e4 | 4.0 | N |
| Q2M | ||||
| 006 | Biopsy for elevated SCr demonstrated BK-related inflammation. Improved after steroid pulse and reduction of MMF | 1e5 | 5.0 | Y |
| 073 | Improved with reduced dose MMF | 1e4 | 4.0 | N |
BVN, BK virus nephropathy; MMF, mycophenolate mofetil; Q1m, every mo dosing; Q2m, every 2-mo dosing; q6, every 6 wk dosing; SCr, serum creatinine.