Figure 2. Combination therapy of MK-4482 and PF-07321332 significantly reduces virus replication in the upper respiratory tract of SARS-CoV-2–infected rhesus macaques.

Viral RNA load in nasal (A) and oral swabs (C). Nasal and oral swabs (n = 5) were collected on 1, 2, and 4 dpi, and viral RNA loads were determined by quantitative RT-PCR targeting sgE RNA. Infectious titers in nasal (B) and oral (D) swabs. Nasal and oral swabs (n = 5) were collected on 1, 2, and 4 dpi, and infectivity was determined by using a TCID assay with virus titers presented as TCID₅₀/mL. Data represent mean. Statistical differences in viral load and infectious virus titers in each study arm were assessed by a 2-way ANOVA using Tukey’s multiple comparisons test (P values, * = 0.01 to 0.05, *** = 0.0001 to 0.001, **** = <0.0001). Nonsignificant results are not indicated.