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. 2023 Feb 22;8(4):e162498. doi: 10.1172/jci.insight.162498

Figure 5. MLBs are released from the apical membrane of PTECs into the tubular lumen in obese mice.

Figure 5

(A and B) Representative electron micrographs of the kidneys (A) and the urine pellets (B) of nonobese and obese Tfebfl/fl mice (n = 2–3). (C) Urinary lipidomics of nonobese and obese mice (n = 5 or 7). Data are presented as the total amount of each lipid species normalized to urine creatinine concentration. Bars: 5 μm (A and B) and 500 nm (B, magnified image). Values represent means ± SEM. Statistically significant differences: #P < 0.05 versus nonobese mice (C, 2-tailed Student’s t test). BM, basement membrane; MLB, multilamellar body; TL, tubular lumen; N, nucleus; BMP, bis(monoacylglycerol) phosphate; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PI, phosphatidylinositol; PS, phosphatidylserine; PG, phosphatidylglycerol; LPC, lysophosphatidylcholine; LPE, lysophosphatidylethanolamine; SM, sphingomyelin; Cer, ceramide; HexCer, hexose ceramide; LacCer, lactosylceramide; FA, fatty acid; MG, monoacylglycerol; DG, diacylglycerol; TG, triacylglycerol; CE, cholesterylester.