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. 2023 Feb 22;8(4):e162498. doi: 10.1172/jci.insight.162498

Figure 8. Higher BMI is associated with increased vacuolation and decreased nuclear TFEB in PTECs of patients with CKD.

Figure 8

(A) Representative images of PAS staining and immunohistochemical staining for TFEB, LAMP1, and SQSTM1/p62 on kidney specimens obtained from obese and nonobese patients. Specimens were counterstained with hematoxylin. Magnified images are shown in the insets (original magnification, ×400). Bars: 50 μm. (B and C) Correlation between BMI and the severity of vacuolar formation (B) (n = 146) and between the percentage of PTECs exhibiting TFEB nuclear translocation and either BMI or the number of vacuoles (C) (n = 30). Relationships were examined using Pearson’s correlation and the corresponding P values. SQSTM1, sequestosome 1.