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. 2022 Dec 8;56(3):e13372. doi: 10.1111/cpr.13372

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© 2022 The Authors. Cell Proliferation published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Embryogenesis was promoted and fertility was recovered in aged mice through endometrial mesenchymal stem cell (EnMSC) mitochondrial transfer. (A) Images of embryos cultured to different stages in the two groups. (B) Early embryogenesis was recorded. The group of aged mice subjected to mitochondrial transfer showed greater blastocyst rates than the control group. (C) Images of pups born after fallopian tube transplantation in the two groups. (D) The numbers of pups were calculated, and the results indicated that the live birth rate was increased in the mito‐group. The data are the mean ± SEM of three replicates; n shows the number of oocytes; and asterisk (*) indicates statistically significant differences (p < 0.05).