Figure 2.

Correlation matrix describing inter-variability of neuropathological measures, summarised across cohorts (ACT, CC75C, CFAS FHS, HAAS, and ROSMAP)

Correlations were first assessed within each cohort individually, and then pooled together using random-effects meta-analysis. Each cohort contributed to a given correlation when the pair of variables of interest in each correlation existed within a given dataset and were not perfectly collinear (no zero contingency cells). Numbers are shown when the correlation is statistically significant at the level of α=0·05. ACT=Adult Changes in Thought. CC75C=Cambridge City over-75s Cohort Study. CERAD=Consortium to Establish a Registry for Alzheimer's disease. CFAS=Cognitive Function and Ageing Studies. FHS=Framingham Heart Study. HAAS=Honolulu-Asia Aging Study. LATE-NC=limbic-predominant age-related TDP-43 encephalopathy neuropathologic change. ROSMAP=Religious Orders Study and Memory and Aging Project.