Table.
Sample characteristics of included cohorts (ROSMAP, ACT, CFAS, CC75C, FHS, and HAAS) and available neuropathologic measures in each cohort
| ACT (n=755) | CC75C (n=241) | CFAS (n=467) | FHS (n=190) | HAAS (n=713) | ROSMAP (n=1988) | ||
|---|---|---|---|---|---|---|---|
| Time period for autopsy collection | 1996–2020 | 1998–2013 | 1989–2011 | 1996–2019 | 1992–2010 | 1994–2022 | |
| Age at death, years | 88·0 (2·8) | 91·6 (4·7) | 89·6 (5·1) | 90·6 (5·6) | 88·7 (4·8) | 90·6 (5·4) | |
| Sex | |||||||
| Women | 442 (59%) | 170 (71%) | 296 (63%) | 112 (59%) | 0 | 1375 (69%) | |
| Men | 313 (41%) | 71 (29%) | 171 (37%) | 78 (41%) | 713 (100%) | 613 (31%) | |
| Race | |||||||
| White | 712 (94%) | 241 (100%) | 467 (100%) | 188 (99%) | 0 | 1897 (96%) | |
| Black | 9 (1%) | 0 | 0 | 0 | 0 | 75 (4%) | |
| Other | 34 (5%) | 0 | 0 | 2 (1%) | 713 (100%) | 4 (<1%) | |
| APOE4 carriers | 205/733 (28%) | 81/227 (36%) | 71/244 (29%) | 45/174 (26%) | 142/700 (20%) | 470/1892 (25%) | |
| Dementia | 371/726 (51%) | 127/230 (55%) | 267/419 (64%) | 90/188 (48%) | 360/548 (66%) | 827/1749 (47%) | |
| Arteriolosclerosis | Yes | Yes | Yes | Yes | No | Yes | |
| Atherosclerosis | Yes | Yes | Yes | Yes | No | Yes | |
| Braak score | Yes | Yes | Yes | Yes | Yes | Yes | |
| CERAD diffuse plaque score | No | Yes | Yes | Yes | No | Yes | |
| CERAD neuritic plaque score | Yes | Yes | Yes | Yes | No | Yes | |
| Cerebral amyloid angiopathy | Yes | Yes | Yes | Yes | Yes | Yes | |
| Hippocampal sclerosis | Yes | Yes | Yes | Yes | Yes | Yes | |
| Lacunes | No | Yes | Yes | Yes | No | Yes | |
| LATE-NC | Yes | Yes | Yes | Yes | No | Yes | |
| Lewy body disease | Yes | Yes | Yes | Yes | Yes | Yes | |
| Macroinfarcts | Yes | Yes | Yes | Yes | Yes | Yes | |
| Microinfarcts | Yes | Yes | Yes | Yes | Yes | Yes | |
Data are n (%), n/N (%), or mean (SD). Yes indicates measure available and no indicates measure not available. ACT=Adult Changes in Thought. CC75C=Cambridge City Over-75s Cohort Study. CERAD=Consortium to Establish a Registry for Alzheimer's disease. CFAS=Cognitive Function and Ageing Studies. FHS=Framingham Heart Study. HAAS=Honolulu-Asia Aging Study. LATE-NC=limbic-predominant age-related TDP-43 encephalopathy. ROSMAP=Religious Orders Study and Memory and Aging Project.