Table 1.
Absolute proportion in self-sampling and control arm, relative participation and participation difference in the self-sampling versus control arm, by the scenario of invitation.
| Absolute participation | Relative participation | Participation difference | |||
|---|---|---|---|---|---|
| Self-sampling | Control | ||||
| Scenario of invitation | # | % (95% CI) | % (95% CI) | (95% CI) | % (95% CI) |
| Per-protocol | |||||
| Mail-to-all | 25/28† | 18.8 (15.7, 22.0) | 10.4 (7.8, 13.4) | 1.93 (1.51, 2.47) | 7.8 (4.7, 10.9) |
| Opt-in | 9/12† | 8.5 (5.6, 11.8) | 11.3 (8.2, 14.9) | 0.80 (0.58, 1.08) | −3.2 (−7.2, 0.9) |
| Community mobilisation & outreach | 5 | 92.5 (80.3, 99.1) | 52.7 (16.7, 87.1) | 1.92 (0.90, 4.10) | 38.5 (9.3, 67.7) |
| Offer at healthcare service | 1 | 42.0 (38.5, 45.6) | 21.6 (18.9, 24.6) | 1.95 (1.66, 2.28) | 20.4 (15.9, 25.0) |
| Intention-to-treat* | |||||
| Mail-to-all | 25/28† | 24.3 (21.5, 27.3) | 10.4 (7.8, 13.4) | 2.50 (2.08, 3.01) | 13.2 (11.0, 15.3) |
| Opt-in | 9/12† | 16.7 (10.5, 23.9) | 11.3 (8.2, 14.9) | 1.45 (1.16, 1.81) | 4.4 (1.2, 7.6) |
| Community mobilisation & outreach | 5 | 92.9 (82.3, 99.0) | 52.7 (16.7, 87.1) | 1.94 (0.89, 4.24) | 39.1 (8.4, 69.9) |
| Offer at healthcare service | 1 | 49.7 (46.1, 53.3) | 21.6 (18.9, 24.6) | 2.30 (1.98, 2.67) | 28.1 (23.5, 32.7) |
*Certain studies reported that some women, allocated to the self-sampling arm, had a Pap smear taken by a clinician. The sum of self-samples taken + Pap smears taken, were counted in the ITT analyses. In studies, where no such cases were reported, the number of events in the PP and ITT analyses were considered equal.
#Number of studies.
†Giorgi et al. [25] and Giorgi et al. [35] had two control groups (one in which a Pap smear was taken by a clinician and another in which a sample for hrHPV testing was taken by a clinician). Kellen et al. [41] also had two control arms (one with recall letters and another without recall letters.