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. 2022 Dec 16;128(5):886–895. doi: 10.1038/s41416-022-02100-1

Fig. 1. Construction of B10 CAR-T cells recognising the HLA-A*24:02/DNAJB8_143 complex.

Fig. 1

a Schematic representation of the B10 CAR construct. b Flow cytometric plots of B10 CAR-T cells. B10 CAR expression was defined as the population that was positive for both HLA-A*24:02/DNAJB8_143 tetramer (DNAJB8 tetramer) and ΔNGFR. CD8-positive cells and CD4-positive cells are coloured blue and green, respectively. The reactivity of HLA-A*24:02/HIV peptide control tetramer against B10 CAR is also shown. c Transduction efficacy of the four independent donors.