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. 2023 Feb 16;11:1101844. doi: 10.3389/fcell.2023.1101844

FIGURE 2.

FIGURE 2

RT-qPCR analysis of miR-122-5p and miR-34a-5p in serum, liver, skeletal muscle and vWAT samples of young and adult rats fed on with a control or fructose-rich diet for 2 weeks. Values are the means ± SEM of six different rats (n = 6). Values with different symbols are significantly different: *p < 0.05 vs. CY; #p < 0.05 vs. CA; $p < 0.05 vs. FY and CA (p < 0.05, Tukey post-test). CY: young rats receiving a standard diet for 2 weeks; FY: young rats receiving a fructose-rich diet for 2 weeks; CA: adult rats receiving a standard diet for 2 weeks; FA: adult rats receiving a fructose-rich diet for 2 weeks. Two-way ANOVA p results: diet effect = 0.0013 and age effect = 0.0695 for serum miR-122-5p, diet effect = 0.0007 and age effect = 0.5406 for serum miR-34a-5p, diet effect = 0.0008 and age effect = 0.0768 for hepatic miR-122-5p, diet effect= <0.0001 and age effect = 0.5336 for hepatic miR-34a-5p, diet effect = 0.0004 and age effect = 0.0156 for skeletal muscle miR-122-5p, diet effect = 0.0006 and age effect = 0.2473 for skeletal muscle miR-34a-5p, diet effect = 0.0113 and age effect = 0.6392 for white adipose tissue miR-122-5p, diet effect = 0.0013 and age effect= <0.0001 for white adipose tissue miR-34a-5p.