Table 4.
Observed d(CGCTAGCG)2:C-1305 (B2L) intermolecular NOE contacts. The intensities were classified as weak/medium/strong on the basis of the integration of the respective crosspeaks in the 2D NOESY spectra (τm = 150 ms) of the complexes and due to the lack of an internal standard of the DNA/ligand relaxation.
| No. | C-1305 proton | DNA proton | B2L (intensity) |
|---|---|---|---|
| NOE contacts involving aromatic protons of the ligand | |||
| 1 | L-H3 | B-T4H1′ | Weak |
| 2 | L-H3 | B-T4H2′ | Medium |
| 3 | L-H3 | B-T4H6 | Medium |
| 4 | L-H7 | A-T4CH3 | Weak |
| 5 | L-H7 | A-T4H1′ | Medium |
| 6 | L-H7 | A-T4H2″ | Medium |
| 7 | L-H7 | A-T4H6 | Medium |
| 8 | L-H9 | A-T4CH3 | Medium |
| 9 | L-H9 | A-T4H6 | Strong |
| 10 | L-H10 | A-T4CH3 | Weak |
| 11 | L-H10 | A-T4H1′ | Strong |
| 12 | L-H10 | A-T4H3′ | Medium |
| NOE contacts involving protons of the aminoalkyl sidechain | |||
| 13 | L-H15 | A-T4H1′ | Strong |
| 14 | L-H15 | B-A5H1′ | Medium |
| 15 | L-H16 | A-T4H1′ | Medium |
| 16 | L-H16 | A-T4H6 | Weak |
| 17 | L-H16 | B-T4H1′ | Weak |
| 18 | L-H16 | B-T4H6 | Weak |
| 19 | L-H17 | A-T4H1′ | Medium |
| 20 | L-H18 | A-T4H1′ | Medium |
| 21 | L-H18 | B-T4H1′ | Medium |
| 22 | L-H18 | B-T4H3′ | Weak |
| 23 | L-H18 | B-A5H1′ | Weak |