Table 2.

Treatment-related adverse events.

Treatment-related adverse events (all grades)
	Dose level 1—75 mg		Dose level 2—150 mg		Dose level 3—250 mg		Dose level 4—375 mg		Dose level 5—450 mg		Dose level 6—625 mg		Dose level 7—750 mg
	N = 4		N = 4		N = 6		N = 3		N = 4		N = 10		N = 17
Toxicity	All grades	Grades 3/4	All grades	Grades 3/4	All grades	Grades 3/4	All grades	Grades 3/4	All grades	Grades 3/4	All grades	Grades 3/4	All grades	Grades 3/4
Haematologic
Anaemia	0	0	2	1	0	0	0	0	0	0	4	0	1	0
Non-haematologic
Hypokalaemia	0	0	1	0	0	0	0	0	0	0	0	0	0	0
Constipation	0	0	0	0	1	0	0	0	0	0	1	0	1	0
Fatigue	0	0	0	0	2	0	0	0	2	0	1	0	7	0
Chills	0	0	0	0	0	0	2	0	0	0	0	0	0	0
Flushing	0	0	0	0	0	0	1	0	0	0	0	0	0	0
Diarrhoea	0	0	0	0	0	0	0	0	1	0	1	0	0	0
Atrial flutter	0	0	0	0	0	0	0	0	0	0	1	0	0	0
Abdominal pain	0	0	0	0	0	0	0	0	0	0	5	0	1	0
Nausea	0	0	0	0	0	0	0	0	0	0	7	0	5	0
Vomiting	0	0	0	0	0	0	0	0	0	0	6	0	6	0
Myalgia	0	0	0	0	0	0	0	0	0	0	1	0	0	0
Dizziness	0	0	0	0	0	0	0	0	0	0	6	0	6	0
Somnolence	0	0	0	0	0	0	0	0	0	0	1	0	0	0
Alopecia	0	0	0	0	0	0	0	0	0	0	1	0	0	0
Weight loss	0	0	0	0	0	0	0	0	0	0	0	0	1	0
Anorexia	0	0	0	0	0	0	0	0	0	0	0	0	4	0
Ataxia	0	0	0	0	0	0	0	0	0	0	0	0	5	1
Headache	0	0	0	0	0	0	0	0	0	0	0	0	4	1
Insomnia	0	0	0	0	0	0	0	0	0	0	0	0	1	0
Tremor	0	0	0	0	0	0	0	0	0	0	0	0	1	0
Peripheral sensory neuropathy	0	0	0	0	0	0	0	0	0	0	0	0	2	0
Generalised muscle weakness	0	0	0	0	0	0	0	0	0	0	0	0	1	0
Nervous system disorder—other	0	0	0	0	0	0	0	0	1	0	0	0	2	0