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. 2022 Dec 16;128(5):907–917. doi: 10.1038/s41416-022-02101-0

Fig. 5. Thrombospondin-1 (TSP1) enhances the effect of gemcitabine chemotherapy on intrahepatic cholangiocarcinoma.

Fig. 5

a The effect of CCK-8 on the proliferation of HCCC9810 and RBE cells under different treatments. b The proliferation ability of HCCC9810 and RBE cells under different treatments in the EdU experiment. c The detection of tumorigenicity of HCCC9810 cells by different treatment methods. d Changes in tumour growth curves corresponding to different treatments (n = 4 per group). Data are shown as mean ± s.d. of n = 3 independent experiments (a,b). MOCK is the blank control, TSP1 is the TSP1 recombinant protein, GEM is gemcitabine, GEM + TSP1 is gemcitabine + TSP1 recombinant protein * represents p < 0.05, * * represents p < 0.01, * * represents p < 0.001.