Table 2.
Safe and tolerable dose ranges.
| IB number | Human equivalent dose (mg) | Cmax (ng/ml) | AUC (ng*h/ml) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NOAEL | HLR | HUR | Ratio HLR/NOAEL | Ratio HUR/NOAEL | NOAEL | HLR | HUR | Ratio HLR/NOAEL | Ratio HUR/NOAEL | NOAEL | HLR | HUR | Ratio HLR/NOAEL | Ratio HUR/NOAEL | |
| 1 | 1440 | 5 | 240 | 288.0 | 6.0 | 7797 | 0 | 774 | 7797.0 | 10.1 | 113,029 | 0 | 5594 | 1,130,29.0 | 20.2 |
| 2 | 0.032 | 0.018 | 0.18 | 1.8 | 0.2 | 1 | 0.398 | 4.55 | 2.5 | 0.2 | 0.8 | 1.54 | 15.7 | 0.5 | 0.1 |
| 3 | 288 | 1 | 1000 | 288.0 | 0.3 | 677 | 0 | 291 | 677.0 | 2.3 | 2760 | 0 | 1910 | 2760.0 | 1.4 |
| 4 | 0.032 | 0.006 | 0.06 | 5.3 | 0.5 | 0.63 | 0 | 1.52 | 0.6 | 0.4 | 0.37 | 0 | 0.456 | 0.0 | 0.8 |
| 5 | 96 | 2.5 | 80 | 38.4 | 1.2 | 167 | 63 | 1030 | 2.7 | 0.2 | 1730 | 324 | 11200 | 5.3 | 0.2 |
| 6 | 6.14 | 0.5 | 20 | 12.3 | 0.3 | 49.3 | 0.343 | 73.3 | 143.7 | 0.7 | 274 | 3.1 | 542 | 88.4 | 0.5 |
| 7 | 105.6 | 1 | 40 | 105.6 | 2.6 | 674.25 | 15 | 497 | 45.0 | 1.4 | 4743 | 57.9 | 2182 | 81.9 | 2.2 |
| 8 | 288 | 5 | 900 | 57.6 | 0.3 | 780 | 18.9 | 2946 | 41.3 | 0.3 | 6336 | 261 | 45,286 | 24.3 | 0.1 |
| 9 | 97.2 | 10 | 600 | 9.7 | 0.2 | 2130 | 9.4 | 1430 | 226.6 | 1.5 | 26,800 | 9 | 5790 | 2977.8 | 4.6 |
| 10 | 78 | 0.05 | 0.8 | 1560.0 | 97.5 | 134 | 0 | 149 | 134.0 | 0.9 | 1763 | 0 | 417 | 1763.0 | 4.2 |
| 11 | 972 | 5 | 1500 | 194.4 | 0.6 | 4445 | 40.1 | 935.9 | 110.8 | 4.7 | 44,200 | 161.4 | 26,585.8 | 273.9 | 1.7 |
| 12 | 32.46 | 0.5 | 1.5 | 64.9 | 21.6 | 609 | 0.22 | 1.4 | 2768.2 | 435.0 | 2421 | 0.29 | 3.55 | 8348.3 | 682.0 |
| 13 | 58.3 | 0.005 | 0.5 | 11,660.0 | 116.6 | 610 | 0.00913 | 0.885 | 66,812.7 | 689.3 | 7584 | 0.245 | 32 | 30,955.1 | 237.0 |
| 14 | 58.3 | 0.04 | 100 | 1457.5 | 0.6 | 1230 | 0.229 | 559.3 | 5371.2 | 2.2 | 9850 | 1.6 | 5753 | 6156.3 | 1.7 |
| 15 | 1623 | 1 | 180 | 1623.0 | 9.0 | 42.9 | 0.572 | 98.8 | 75.0 | 0.4 | 108 | 12.1 | 8666 | 8.9 | 0.0 |
| 16 | 267.8 | 10 | 80 | 26.8 | 3.3 | 1270 | 183 | 1208 | 6.9 | 1.1 | 3570 | 982 | 3648 | 3.6 | 1.0 |
| 17 | 874.8 | 30 | 450 | 29.2 | 1.9 | 3267 | 66.3 | 1130 | 49.3 | 2.9 | NR | 743 | 14,600 | NR | NR |
| 18 | 973 | 5 | 200 | 194.6 | 4.9 | 3560 | 159.7 | 1868.9 | 22.3 | 1.9 | 10,900 | 971.3 | 22,906.4 | 11.2 | 0.5 |
| 19 | 486.9 | 50 | 450 | 9.7 | 1.1 | 1740 | 138 | 1180 | 12.6 | 1.5 | 27,200 | 2456 | 22,357 | 11.1 | 1.2 |
| 20 | 32.5 | 1 | 35 | 32.5 | 0.9 | 267 | 3.4 | 235 | 78.5 | 1.1 | 1990 | 42 | 2210 | 47.4 | 0.9 |
| 21 | 19.4 | 5.5 | 44 | 3.5 | 0.4 | 27.1 | 10.7 | 58.5 | 2.5 | 0.5 | 34.8 | 15.7 | 119 | 2.2 | 0.3 |
| 22 | 560 | 1 | 120 | 560.0 | 4.7 | 6976 | 97.4 | 4575 | 71.6 | 1.5 | NR | 1969 | 64,642 | NR | NR |
| 23 | 811 | 3 | 90 | 270.3 | 9.0 | 4433 | 110 | 3200 | 40.3 | 1.4 | 55,333 | 1600 | 84,700 | 34.6 | 0.7 |
| 24 | 1920 | 2.5 | 375 | 768.0 | 5.1 | 33,300 | 32.5 | 3520 | 1024.6 | 9.5 | 289,000 | 286 | 46,500 | 1010.5 | 6.2 |
| 25 | 19.44 | 0.3 | 18 | 64.8 | 1.1 | 359 | 2.93 | 126 | 122.5 | 2.8 | 1069 | 47.7 | 8882 | 22.4 | 0.1 |