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. 2023 Jan 12;101(1-2):151–169. doi: 10.1007/s00109-022-02280-6

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Fig. 8 — Enhanced activation of SOCS3 mRNA in PKM2 knockdown keratinocytes. A The expression of SOCS3 mRNA in EGF-stimulated HaCaTs was assessed by RT-PCR (left), and the fold induction of enhanced expression of SOCS3 in PKM2 knockdown cells as compared to stimulation of control siRNA transfected cells was evaluated by the 2^−ΔΔCt method (right). Bars indicate means ± SD obtained from three independent experiments (n = 3) performed in triplicate; *P < 0.05 (unpaired Student’s t-test). B The expression of SOCS3 mRNA upon stimulation with IL-6 (20 ng/ml) was quantified by RT-PCR (left). IL-6 stimulation of SOCS3 mRNA expression is markedly increased upon targeting PKM2 expression as compared to stimulation of control siRNA transfected cells (right). Bars indicate means ± SD obtained from three independent experiments (n = 3) performed in triplicate; **P < 0.01 and *P < 0.05 (one-way ANOVA) (Bonferroni’s post-hoc test). The fold of stimulation in A and B is indicated on top of the bars (A and B)