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. 2023 Mar 1;14(3):176. doi: 10.1038/s41419-023-05672-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Left panel: in the cortical areas, a consistent proportion of p-α-syn⁺ neurons was detected in α-syn-PFFs-injected rats. Analysis of spontaneous synaptic currents indicates an increased frequency of the spontaneous excitatory postsynaptic current in target neurons of the dorsal striatum that brings to a state of hyperglutamatergic activity. Right panel: the SNpc in α-syn-PFF rats presents a reduced number of dopaminergic neurons as displayed by a decrease of TH⁺-immunofluorence, associated with an abnormal increase in spontaneous firing activity. Center panel: in the dorsolateral striatum, α-syn-PFFs injection leads to profound alterations of the corticostriatal long-term plasticity, in the SPNs. A significant decrease of TH⁺ fibers and a reduced release of endogenous dopamine from SNpc terminals are also observed.