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. 2023 Mar 1;14(3):175. doi: 10.1038/s41419-023-05615-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Representative TEM images in normal adjacent non-tumor livers (HC) and biliary atresia (BA) livers. Red arrows indicate enlarged mitochondria, blue arrows indicate swollen nucleus, and yellow arrows indicate enlarged vacuoles. Scale bar: 2 μm. B Representative TUNEL staining images in HC and BA livers. Yellow arrows: TUNEL⁺ cells. Scale bar: 45 μm. C Western blot analysis for p-MLKL and ZBP1 in the liver tissues from BA (n = 8) and HC (n = 6). Blots of p-MLKL were normalized to MLKL, and blots of ZBP1 were normalized to α-tubulin. D Representative image of TUNEL (green) and p-MLKL (pink) staining in BA livers. Yellow arrows: TUNEL⁺p-MLKL⁺ cells. Scale bar: 20 μm. E Representative images of p-MLKL (green) or ZBP1 (green) staining. The nuclei were stained with DAPI (blue). Yellow arrows: p-MLKL⁺ or ZBP1⁺ cells. Scale bar: 30 μm. Data are presented as the mean ± SEM. **p < 0.01, ****p < 0.0001 (versus control).