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. 2023 Mar 1;8:92. doi: 10.1038/s41392-023-01347-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 12 — Antibody drugs against p53. a Structure of the Nb139/p53-DBD complex. p53-DBD shown as cartoon/surface (colored pink). Nb139 shown as cartoon (colored marine). b Mechanism of action and structure of the bispecific antibody H2-scDb. H2-scDb is a bispecific antibody that recognizes the p53^R175H mutant peptide presented on the cell surface by HLA-A and binds to the T-cell receptor, activating T cells and releasing cytokines to kill tumor cells. The interacting amino acid residues are shown as sticks. Hydrogen bonds as black lines