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The role of mutant p53 in cancer. Mutant p53 can result in loss-of-function of wild-type p53, dominant-negative repression of wild-type p53 by mutant p53, and gain-of-function with oncogenic properties. Mutant p53 affects various cellular responses, such as genomic instability, metabolic reprogramming, and tumor microenvironment, and promotes cancer cell proliferation, invasion, metastasis and drug resistance. WT wild-type
