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. 2023 Mar 1;8:92. doi: 10.1038/s41392-023-01347-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Structure of MDM2/X with small molecules. a Overlay of the crystal structures of MDM2/p53-TAD (white, sky blue), MDMX/p53-TAD (greencyan, pink) and the three residues of p53-TAD (F19, W23, L26) are shown as sticks. b MDM2 is shown as a surface. c MDMX is shown as surface. d MDM2/RG7112 (PDB: 4IPF). e MDM2/RG7388 (PDB: 4JRG). f MDM2/AMG 232 (PDB: 4OAS). g MDM2/MI-77301 (PDB: 5TRF). h MDM2/NVP-CGM097 (PDB: 4ZYF). Water molecules are red spheres, and hydrogen bonds are black lines. The interacting amino acid residues are shown as sticks (colored gray)