Table 3.
Scope of rescue drugs for mutant p53
| Drugs | p53-DNA contact | Restore the p53 structure | Refs |
|---|---|---|---|
| PRIMA/APR-246 | R248Q, R273H | R175H | 386,410 |
| ATO | – | Structural mutants: R175H, G245S, R249S, R282W and so on. | 431 |
| PAT | – | Temperature-sensitive mutants: V272M, P278A, Q136P and so on. | 432 |
| ZMC1 | – | R175H | 441 |
| UCI-LC0023 | – | R175H | 462 |
|
PhiKan083 PhiKan5196 PK7088 (PK7242) Compound9 Compound6 PK11007 MB710 L5 PK9318 LI LH PC14586 |
– | Y220C | 467–478 |
| ReAcp53 | R248Q | R175H | 490 |
| ADH-6 | R248W | – | 496 |
| Peptide 46 | R273H | – | 549 |
| CDB3 | R273H | R175H, G245S, R249S | 507,510 |
| pCAPs | R273H | R175H, R280H and so on. | 511 |