Table 3.
Replication of the causalities from Terrisporobacter to LDL-C and TC.
| Exposure | Outcome | Method | nSNP | Beta (95%CI) | P-value | F-statistics | P Heterogeneity | P Pleiotropy | P Global Test |
|---|---|---|---|---|---|---|---|---|---|
| Genus Terrisporobacter | LDL-C | Inverse-variance weighted | 13 | 0.021 (0.005,0.037) | 9.13E-03 | 0.88 | 0.44 | 21.98 | 0.90 |
| Maximum likelihood | 0.022 (0.005,0.038) | 9.74E-03 | |||||||
| MR Egger | 0.007(−0.03,0.045) | 7.06E-01 | |||||||
| Weighted median | 0.023 (0.001,0.045) | 4.13E-02 | |||||||
| Weighted mode | 0.03(−0.005,0.065) | 1.16E-01 | |||||||
| Genus Terrisporobacter | TC | Inverse-variance weighted | 13 | 0.023 (0.007,0.039) | 4.33E-03 | 0.39 | 0.45 | 21.87 | 0.42 |
| Maximum likelihood | 0.024 (0.008,0.04) | 3.95E-03 | |||||||
| MR Egger | 0.009(−0.029,0.048) | 6.40E-01 | |||||||
| Weighted median | 0.017(−0.005,0.039) | 1.21E-01 | |||||||
| Weighted mode | 0.005(−0.036,0.046) | 8.06E-01 |
nSNP, number of the SNP used as the IVs for the MR analyses; 95% CI, 95% confidence interval; PHeterogeneity, p-value of the heterogeneity test; PPleiotropy, p-value of the intercept of the MR Egger; PGlobal test, p-value of the MR-PRESSO global test.