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. 2023 Feb 16;14:1107437. doi: 10.3389/fimmu.2023.1107437

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Copyright © 2023 Westhölter, Raspe, Uebner, Pipping, Schmitz, Straßburg, Sutharsan, Welsner, Taube and Reuter

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of Pseudomonas aeruginosa infection on regulatory T cells (Tregs). Data showed are for CD25⁺ CD127^- Treg (as a proportion of T helper cells), stratified for P. aeruginosa infection. PwCF with chronic P. aeruginosa infection tended to have lower percentages of Tregs (black) compared to PwCF without chronic P. aeruginosa infection (grey) before therapy (T0). Treg impairment in PwCF with P. aeruginosa infection appeared to be rebalanced at T1 and T2. Values are median, and p-values were determined using the Wilcoxon signed rank test. ***p < 0.001.